Evaluation of Circulating Nitric Oxide Levels in Patients with Complex Regional Pain Syndrome Type 1
نویسندگان
چکیده
Objectives: Proinflammatory mediators play an important role in the pathophysiology and development of complex regional pain syndrome type 1. Elevated cytokine production is suggested to increase nitric oxide production by activating the inducible nitric oxide synthase pathway. In this study, we aimed to determine the circulating nitric oxide concentrations in complex regional pain syndrome type 1 patients, and to compare them with those of healthy controls. Methods: Serum circulating nitric oxide concentrations were measured in twenty-five patients (15 female and 10 male) with complex regional pain syndrome type 1 who fulfillied the criteria of the modified International Association for the Study of Pain (IASP) and compared those of twentyfive (15 female and 10 male) age, gender matched healthy subjects. Nitric oxide concentration is estimated indirectly based on Greiss method by measuring the combined oxidation products of nitric oxide (total nitrites and nitrates). Results: There was no significant difference in the demographic data among two groups (p>0.05). The mean serum nitric oxide concentration (39.50±13.26 μmol) was significantly higher in the complex regional pain syndrome type 1 patients group compared to those of controls (27.15±11.90 μmol) (p<0.001). Conclusions: We suggest that nitric oxide levels play an important role on inflammatory reactions in CPRS 1 patients.
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Author's response to reviews Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate Title: cold type complex regional pain syndrome type 1 Authors: J. George Groeneweg ([email protected])
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Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1
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